The clinical efficacy of inhaled corticosteroids (ICSs) in asthma has been demonstrated in long-term intervention studies,1 2 and ICSs are recommended first-line treatment of persistent asthma, even in children.3 The...
Sam 28 01 2012 Bibliographie
Idiopathic pulmonary fibrosis (IPF) is a chronic progressive disease of unknown aetiology. It has a very poor prognosis and no effective treatment. There are two major barriers to the development...
Sam 28 01 2012 Bibliographie
The goal of asthma treatment is to prevent exacerbations, achieve daily asthma control and prevent adverse effects with a minimum of medication. In preschoolers, children and adolescents with mild persistent...
Sam 28 01 2012 Bibliographie
Background Organic dust is a complex mixture of particulate matter from microbial, plant or animal origin. Occupations with exposure to animal products have been associated with an increased lung cancer risk,...
Sam 28 01 2012 Bibliographie
Background Rates of mortality and readmission are high in patients hospitalised with acute exacerbations of chronic obstructive pulmonary disease (AECOPD). In this population, the prognostic value of the Medical Research Council...
Sam 28 01 2012 Bibliographie
CONCLUSION: This study describes for the first time an association between neutrophils and IgLC in the pathophysiology of COPD, which could open new avenues to targeted treatment of this chronic...
Sam 28 01 2012 Bibliographie
Anaphylaxis is a rare adverse event following immunisation (AEFI) and unlikely to be detected in prelicensure vaccine trials. Previous retrospective studies have been hampered by the paucity of information available...
Ven 27 01 2012 Bibliographie
Urticaria is a skin disease characterised by short-lived surface swellings of the dermis (wheals) frequently accompanied by itching. It is classified as acute or chronic depending on whether the wheal...
Ven 27 01 2012 Bibliographie
Natural killer T (NKT) cells have been reported to play a crucial role in the pathogenesis of asthma in a mouse model of acute asthma. The present study aimed to...
Ven 27 01 2012 Bibliographie
A wide range of reported evidence in the literature has shown that the quantification of basophil activation by flow cytometry (basophil activation test, BAT) has proven to be a useful...
Ven 27 01 2012 Bibliographie
Psychosocial stress and asthma morbidity. Curr Opin Allergy Clin Immunol. 2012 Jan 19; ...
Ven 27 01 2012 Bibliographie
The regulation of fibrosis in airway remodeling in asthma. Mol Cell Endocrinol. 2012 Jan 14; ...
Ven 27 01 2012 Bibliographie
Omalizumab beyond asthma. Allergol Immunopathol (Madr). 2012 Jan 18; ...
Ven 27 01 2012 Bibliographie
Efficacy of inhaled N-acetylcysteine monotherapy in patients with early stage idiopathic pulmonary fibrosis. Respirology. 2012...
Ven 27 01 2012 Bibliographie
The diagnosis of influenza A/H1N1 is mainly clinical, particularly during peak or seasonal flu outbreaks. A diagnostic test should be performed in all patients with fever and flu symptoms that...
Jeu 26 01 2012 Bibliographie
Sex differences in the biology of different organ systems and the influence of sex hormones in modulating health and disease are increasingly relevant in clinical and research areas. Although work...
Jeu 26 01 2012 Bibliographie
New paradigms have been recently proposed in the pathogenesis of both chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF), evidencing surprising similarities between these deadly diseases, despite their...
Jeu 26 01 2012 Bibliographie
Gastro-oesophageal reflux disease (GORD) has been implicated in the worsening of several respiratory disorders. Current methods of diagnosis lack accuracy, are invasive and can be costly. Recently, novel methods of...
Jeu 26 01 2012 Bibliographie
After two decades of ups and downs, gene therapy has recently achieved a milestone in treating patients with Leber's congenital amaurosis (LCA). LCA is a group of inherited blinding diseases...
Jeu 26 01 2012 Bibliographie
It is well known that pulmonary tuberculosis is associated with an increased risk of lung cancer. We investigated whether a history of pulmonary tuberculosis is an independent risk factor for...
Jeu 26 01 2012 Bibliographie
A wide spectrum of thoracic tumors have known or suspected viral etiologies. Oncogenic viruses can be classified by the type of genomic material they contain. Neoplastic conditions found to have...
Jeu 26 01 2012 Bibliographie
To evaluate, among older persons, the association between respiratory impairment and hospitalization for chronic obstructive pulmonary disease (COPD), based on spirometric Z-scores (Lambda-Mu-Sigma [LMS]) and a competing risk approach. Using data...
Mer 25 01 2012 Bibliographie
In this study we investigated whether DNA double-strand breaks (DSBs) contribute to the pathogenesis of COPD. We immunofluorescence-stained lung tissue samples obtained from COPD patients, asymptomatic smokers, and nonsmokers for markers...
Mer 25 01 2012 Bibliographie
Fluticasone furoate/vilanterol (FF/VI) is a novel once-daily (OD) inhaled corticosteroid/long-acting β(2) agonist combination in development for chronic obstructive pulmonary disease (COPD) and asthma. Trial design A multicentre, randomised, double-blind, parallel-group, placebo-controlled...
Mer 25 01 2012 Bibliographie
Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and mortality worldwide and a significant challenge for adult physicians. However, there is a misconception that COPD is a...
Mer 25 01 2012 Bibliographie
The purpose of this review article is to provide an up-to-date summary on the current evidence for or against the use of lung function tests as screening and diagnostic tools...
Mer 25 01 2012 Bibliographie
Chronic obstructive pulmonary disease (COPD) is a crippling disease with a high worldwide prevalence. The purpose of this review is to highlight recent studies which define the global impact of...
Mer 25 01 2012 Bibliographie
Chronic obstructive pulmonary disease (COPD) patients with mucus hypersecretion tend to demonstrate increased frequency of infective exacerbations and a steeper slope of decline in lung function. Enhanced mucociliary clearance with...
Mer 25 01 2012 Bibliographie
It is a common clinical experience that patients with chronic obstructive pulmonary disease (COPD) complain of airway symptoms provoked by environmental irritants like chemicals and scents, although few studies can...
Mer 25 01 2012 Bibliographie
Adjusting for COPD severity in database research: developing and validating an algorithm. Int J...
Mer 25 01 2012 Bibliographie
Why are some evidence-based care recommendations in chronic obstructive pulmonary disease better implemented than others? Perspectives of medical practitioners. ...
Mer 25 01 2012 Bibliographie
Asthma is a chronic airway disease characterized by paroxysmal airflow obstruction evoked by irritative stimuli on a background of allergic lung inflammation. Currently, there is no cure for asthma, only...
Mar 24 01 2012 Bibliographie
An associative and mechanistic link between chronic obstructive pulmonary disease (COPD) and lung cancer has long been suspected. This review describes the current understanding of the incidence, mechanism of association,...
Mar 24 01 2012 Bibliographie
During epidemics, influenza attack rates in children may exceed 40%. Options for prevention and treatment currently include the neuraminidase inhibitors zanamivir and oseltamivir. Laninamivir octanoate, the prodrug of laninamivir, is...
Mar 24 01 2012 Bibliographie
Work-related asthma (WRA) is a relevant problem in several countries, is cause of disability and socioeconomic consequences for both the patient and the society and is probably still underdiagnosed. A...
Mar 24 01 2012 Bibliographie
Severe asthma is considered a heterogeneous disease in which a variety of clinical, physiological and inflammatory markers determine disease severity. Pivotal studies in the last 5 years have led to substantial...
Mar 24 01 2012 Bibliographie
Asthma, and severe asthma, in particular, is increasingly recognized as a heterogeneous disease. While traditional views of asthma have centered around a childhood onset disease with an allergic component, several...
Mar 24 01 2012 Bibliographie
Approximately 4% to 12% of pregnant women have asthma; few studies have examined the effects of maternal asthma medication use on birth defects. We examined whether maternal asthma medication use...
Mar 24 01 2012 Bibliographie
PURPOSE OF REVIEW: Children with severe asthma have a high degree of respiratory morbidity despite treatment with high doses of inhaled corticosteroids and are therefore very difficult to treat. This...
Mar 24 01 2012 Bibliographie
The mechanism by which budesonide/formoterol combination therapy exerts clinically beneficial effects appears to be related to increased anti-inflammatory activity and attenuation of aspects of airway remodeling in asthmatic patients. Background and...
Mar 24 01 2012 Bibliographie
Noninvasive Ventilation for Acute Exacerbations of Chronic Obstructive Pulmonary Disease: "Don't Think Twice, It's Alright!". Am J Respir Crit Care Med. 2012 Jan 15;185(2):121-3 Authors: Elliott MW, Nava S PMID: 22246701…
Authors: Stirling RG, Nicolson CH, Button BM, Wilson JW PMID: 22246705 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
CONCLUSIONS: HIF-1α-mediated Glut1 upregulation in proliferating vascular cells in PAH accounts for increased lung FDG-PET uptake. FDG-PET is sensitive to mild PAH and can monitor therapeutic changes in the vasculature. PMID: 22246173 [PubMed - as supplied by…
Authors: Laurin C, Moullec G, Bacon SL, Lavoie KL Abstract Chronic Obstructive Pulmonary Disease (COPD) exacerbations contribute significantly to morbidity and mortality. COPD is also associated with high levels of psychological distress, which has…
The impact of cormorbid conditions on critical illness. Crit Care Med. 2011 Dec;39(12):2728-35 Authors: Esper AM, Martin…
Omalizumab may inhibit allergic inflammation and could contribute to decreasing airway remodeling in patients with asthma. Objective: The aim of this study was to assess the effects of omalizumab on airway wall thickness using computed tomography (CT). Methods: Thirty patients…
No abstract available Source: RespirationAuthor : Stephan F. Van EedenRead Full Article
Neutrophils and oxidative stress have been implicated in the pathogenesis of COPD. Severe, early-onset COPD is characterized by a rapid decline in the lung function at an early age; however, nothing is known about neutrophil activation in…
Cough variant asthma (CVA) is a phenotype of asthma presenting solely with coughing, characterized by airway hyperresponsiveness, eosinophilic inflammation and a cough response to bronchodilators. Leukotriene receptor antagonists (LTRAs) are antiasthma medications with anti-inflammatory and bronchodilatory…
Asthma and chronic obstructive pulmonary disease (COPD) have major symptoms in common. However, the mode of the underlying chronic airway inflammation is different. There is still no single diagnostic test that can be considered a gold standard…
The researchers studied the immune response of 107 pregnant women after they were injected with a single dose of non-adjuvant H1N1 vaccine. They concluded that the influenza shot boosted the immune response in pregnant women and at the same time…
Findings published in The Journal of Infectious Diseases show that statins, one of the most widely sold drugs today, that are more commonly used for combating high cholesterol levels, may have a new use in helping fight influenza in critically…
I hope that fear of terrorism will not lead to the suppression of valuable research about engineering the H5N1 virusA few months ago, Dutch virologist Ron Fouchier made what he hoped would be a low-key announcement at a conference on…
Reassortant H1 swine influenza viruses (SIVs) carrying 2009 pandemic H1N1 virus (pH1N1) genes have been isolated from pigs worldwide. Seven novel reassortant H3N2 SIVs were identified from diseased pigs in the USA from winter 2010 to spring 2011. …
Since July, 12 patients have caught a swine influenza virus that borrows a gene from the 2009 pandemic virus. In 2 states, the virus apparently spread from person to person on a limited basis.
CDC received reports of 12 human infections with influenza A (H3N2)v viruses that have the matrix (M) gene from the influenza A (H1N1)pdm09 virus (formerly called swine-origin influenza A [H3N2] and pandemic influenza A [H1N1] 2009 viruses, respectively). The 12 cases…
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