Treatment Of Copd The Sooner The Better

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Demographic, Physiologic and Radiographic Characteristics of COPD Patients Taking Chronic Systemic Corticosteroids.

Demographic, Physiologic and Radiographic Characteristics of COPD Patients Taking Chronic Systemic Corticosteroids. COPD. 2012 Feb;9(1):29-35 ...

Sam 04 02 2012 Bibliographie

Diffusing Capacity for Carbon Monoxide is Linked to Ventilatory Demand in Patients with Chronic Obstructive Pulmonary Disease.

Diffusing Capacity for Carbon Monoxide is Linked to Ventilatory Demand in Patients with Chronic Obstructive Pulmonary Disease. ...

Sam 04 02 2012 Bibliographie

Colonisation with Pseudomonas aeruginosa and antibiotic resistance patterns in COPD patients.

Colonisation with Pseudomonas aeruginosa and antibiotic resistance patterns in COPD patients. Swiss Med Wkly. 2012;142:0 ...

Sam 04 02 2012 Bibliographie

Diagnostic management of chronic obstructive pulmonary disease.

Diagnostic management of chronic obstructive pulmonary disease. Neth J Med. 2012 Jan;70(1):6-11 ...

Sam 04 02 2012 Bibliographie

Update on mortality in COPD - report from the OLIN COPD study.

Update on mortality in COPD - report from the OLIN COPD study. BMC Pulm Med....

Sam 04 02 2012 Bibliographie

Nocturnal gastroesophageal reflux, lung function and symptoms of obstructive sleep apnea: Results from an epidemiological survey.

Nocturnal gastroesophageal reflux, lung function and symptoms of obstructive sleep apnea: Results from an epidemiological survey. ...

Sam 04 02 2012 Bibliographie

Systemic CD4+ and CD8+ T cell cytokine profiles correlate with GOLD stage in stable COPD.

Systemic CD4+ and CD8+ T cell cytokine profiles correlate with GOLD stage in stable COPD. ...

Sam 04 02 2012 Bibliographie

Tissue engineering for pulmonary diseases – insights from the laboratory

Advances in stem cell research and tissue engineering have opened new paradigms for future therapies toward many intractable diseases. Many tissue engineering approaches are also applied in the pulmonary research...

Ven 03 02 2012 Bibliographie

Low‐dose Azithromycin improves phagocytosis of bacteria by both alveolar and monocyte‐derived macrophagesin COPD subjects

Conclusions : The data provide further support for the long term use of low dose azithromycin as an attractive adjunct treatment option for COPD. Improved clearance of both apoptotic cells...

Ven 03 02 2012 Bibliographie

Efficacy and safety of indacaterol 150 and 300 µg in chronic obstructive pulmonary disease patients from six Asian areas including Japan: A 12‐week, placebo‐controlled study

Conclusions : Indacaterol provided clinically significant bronchodilation and improvements in dyspnoea and health status in Asian COPD patients.

Ven 03 02 2012 Bibliographie

Evaluation of the asthma control test: A reliable determinant of disease stability and a predictor of future exacerbations

Conclusions : Single measurement of ACT is useful for assessing asthma control, prediction of exacerbation and changes in treatment decisions.

Ven 03 02 2012 Bibliographie

The science behind the 7th edition Tumour, Node, Metastasis staging system for lung cancer

The Tumour, Node, Metastasis (TNM) system for classifying lung cancer is the cornerstone of modern lung cancer treatment and underpins comparative research; yet is continuously evolving through updated revisions. The recently...

Ven 03 02 2012 Bibliographie

Obesity, obstructive sleep apnoea and metabolic syndrome

OSA is increasingly recognized as a major health problem in developed countries. Obesity is the most common risk factor in OSA and hence, the prevalence of OSA is undoubtedly rising...

Ven 03 02 2012 Bibliographie

Efficacy of inhaled N‐acetylcysteine monotherapy in patients with early stage idiopathic pulmonary fibrosis

Conclusions : These findings indicate that NAC monotherapy may have some beneficial effect in patients with early stage IPF. Further trials, in more select IPF populations with progressive disease, are required...

Ven 03 02 2012 Bibliographie

Effects of budesonide/formoterol combination therapy versus budesonide alone on airway dimensions in asthma

Ven 03 02 2012 Bibliographie

New therapy options for MRSA with respiratory infection/pneumonia.

Methicillin-resistant Staphylococcus aureus (MRSA) is a frequent causative agent of nosocomial pneumonia. Because of important clinical consequences of inappropriate treatment, a current review of the potential modifications undergone by S....

Jeu 02 02 2012 Bibliographie

Is healthcare-associated pneumonia a distinct entity needing specific therapy?

Healthcare-associated pneumonia (HCAP) was introduced in 2005 by American Thoracic Society/Infectious Diseases Society of America guidelines as a new entity of pneumonia, resembling nosocomial pneumonia rather than community-acquired pneumonia (CAP)...

Jeu 02 02 2012 Bibliographie

Macrolides for the therapy of nosocomial infections.

Nosocomial infections are an emerging threat. Available solutions are limited due to the multidrug-resistance pattern of the pathogens. Macrolides modulate the immune function of the host and may be active...

Jeu 02 02 2012 Bibliographie

PET imaging of patients with non-small cell lung cancer employing an EGF receptor targeting drug as tracer.

We have previously developed (11)C-erlotinib as a new positron emission tomography (PET) tracer and shown that it accumulates in epidermal growth factor receptor (EGFR)-positive lung cancer xenografts in mice. Here,...

Jeu 02 02 2012 Bibliographie

Diagnosis and management of anaemia and iron deficiency in patients with haematological malignancies or solid tumours in France in 2009-2010: the AnemOnHe study.

OBJECTIVE: To describe the management of anaemia in 2009-2010 in France in patients with haematological malignancies (HM) or solid tumours (ST). METHODS: Retrospective observational study in 57 centres, enrolling adult...

Jeu 02 02 2012 Bibliographie

Establishing an EGFR mutation screening service for non-small cell lung cancer - sample quality criteria and candidate histological predictors.

EGFR screening requires good quality tissue, sensitivity and turn-around time (TAT). We report our experience of routine screening, describing sample type, TAT, specimen quality (cellularity and DNA yield), histopathological description,...

Jeu 02 02 2012 Bibliographie

Environmental Measures in Domicilliary Interventions of Asthmatic Children.

OBJECTIVE: To evaluate the impact of environmental interventions...

Jeu 02 02 2012 Bibliographie

Management of primary ciliary dyskinesia in European children: recommendations and clinical practice.

The European Respiratory Society task force on primary ciliary dyskinesia (PCD) in children recently published recommendations for diagnosis and management. This paper compares these recommendations with current clinical practice in...

Jeu 02 02 2012 Bibliographie

Risk Factors and Mycobacterium avium Complex

Background: The cause of observed increases in pulmonary Mycobacterium avium complex (pMAC) isolation and disease is unexplained. To explore possible causes of the increase in pMAC isolation and disease prevalence in...

Mer 01 02 2012 Bibliographie

Severity of Asthma Score Predicts Outcomes

Background: The severity of asthma (SOA) score is based on a validated disease-specific questionnaire that addresses frequency of asthma symptoms, use of systemic corticosteroids, use of other asthma medications, and history...

Mer 01 02 2012 Bibliographie

Hot off the breath: triple therapy for idiopathic pulmonary fibrosis--hear the PANTHER roar

Idiopathic pulmonary fibrosis (IPF) is a disease characterised by alveolar epithelial damage followed by an aberrant repair mechanism characterised by fibroblast foci and activated myofibroblasts.1 Despite an incidence of 7.4/100...

Mer 01 02 2012 Bibliographie

Gene expression networks in COPD: microRNA and mRNA regulation

Background The mechanisms underlying chronic obstructive pulmonary disease (COPD) remain unclear. MicroRNAs (miRNAs or miRs) are small non-coding RNA molecules that modulate the levels of specific genes and proteins. Identifying expression...

Mer 01 02 2012 Bibliographie

MicroRNAs in lung diseases

The advent of RNA sequencing technology has stimulated rapid advances in our understanding of the transcriptome, including discovery of the vast RNA complement generated by transcript splice variation and the...

Mer 01 02 2012 Bibliographie

Chronic bronchitis phenotype in subjects with and without COPD: the PLATINO study.

Little information exists regarding the epidemiology of chronic bronchitis (CB) phenotype in unselected COPD populations. We examined the prevalence of CB phenotype in COPD and non-COPD subjects of the PLATINO...

Mar 31 01 2012 Bibliographie

Utility of the COPD Assessment Test™ (CAT) to Evaluate Severity of COPD Exacerbations.

The COPD Assessment Test™ (CAT) is an 8-item questionnaire designed to assess and quantify the impact of COPD symptoms on health status. COPD exacerbations impair quality of life and are...

Mar 31 01 2012 Bibliographie

Prognostic value of the objective measurement of daily physical activity in COPD patients.

Subjective measurement of physical activity using questionnaires has prognostic value in COPD. However, their lack of accuracy and large individual variability limit their use for evaluation on an individual basis....

Mar 31 01 2012 Bibliographie

Tests of the Responsiveness of the Chronic Obstructive Pulmonary Disease (COPD) Assessment Test TM (CAT) Following Acute Exacerbation and Pulmonary Rehabilitation.

The chronic obstructive pulmonary disease (COPD) Assessment Test™ (CAT) is an eight-item questionnaire suitable for routine clinical use that shows reliability and validity in stable and exacerbating COPD. METHODS:Study 1 assessed...

Mar 31 01 2012 Bibliographie

Complexity of Medication Use in Newly Diagnosed Chronic Obstructive Pulmonary Disease Patients.

To better understand how medications have been used and the complexity of regimens used to treat patients, we characterized patterns of medication use and the degree to which patients used...

Mar 31 01 2012 Bibliographie

Imaging in pulmonary hypertension, part 3: small vessel diseases

Pulmonary hypertension is a significant cause of morbidity and mortality. Unfortunately, non-specific presentation and lack ...

Mar 31 01 2012 Bibliographie

Imaging in pulmonary hypertension, part 1: clinical perspectives, classification, imaging techniques and imaging algorithm

Pulmonary arterial hypertension (PAH) is an uncommon condition associated with significant morbidity and mortality. It has diverse aetiology with differing clinical presentations, imaging features and treatments that range...

Mar 31 01 2012 Bibliographie

Imaging in pulmonary hypertension, part 2: large vessel diseases.

Pulmonary hypertension is defined by physiological parameters but there are numerous causes that differ in their pathogenesis, management and prognosis. Causes include chronic cardiac or pulmonary diseases and diffuse small...

Mar 31 01 2012 Bibliographie

Chlamydophila pneumonia inhibits the corticosteroid-induced suppressions of metalloproteinase-9 and tissue inhibitor metalloproteinase-1 secretion by human peripheral blood mononuclear cells.

Chlamydophila pneumoniae infection has been suggested to be associated with severe asthma characterized by persistent airway limitation, which may be related to airway remodeling. We investigated whether C. pneumoniae infection affected...

Lun 30 01 2012 Bibliographie

Inhaled antibiotics for nosocomial pneumonia.

Pneumonia, especially the more severe forms, is associated with considerable morbidity and mortality. Systemic use of antibiotics is the cornerstone of the management of pneumonia in all patients, including critical...

Lun 30 01 2012 Bibliographie

Factors associated with the initiation of proton pump inhibitors in corticosteroid users.

Proton pump inhibitors (PPIs) and corticosteroids are commonly prescribed drugs; however, each has been associated with fracture and community-acquired pneumonia. How physicians select patients for co-therapy may have implications for...

Lun 30 01 2012 Bibliographie

Antiviral Therapy and Outcomes of Patients with Pneumonia Caused by Influenza A Pandemic (H1N1) Virus.

Antiviral Therapy and Outcomes of Patients with Pneumonia Caused by Influenza A Pandemic (H1N1) Virus. ...

Lun 30 01 2012 Bibliographie

Focal Organizing Pneumonia Mimicking Lung Cancer: A Surgeon's View.
Focal Organizing Pneumonia Mimicking Lung Cancer: A Surgeon's View. Am Surg. 2012 Jan;78(1):133-7 Authors: Zheng Z, Pan…
Community-Acquired pneumonia in outpatients: etiology and outcomes.
Community-Acquired pneumonia in outpatients: etiology and outcomes. Eur Respir J. 2012 Jan 20; Authors: Cillóniz C, Ewig…
Changes in epidemiology, clinical features and severity of influenza A (H1N1) 2009 pneumonia in the first post-pandemic influenza season.
Changes in epidemiology, clinical features and severity of influenza A (H1N1) 2009 pneumonia in the first post-pandemic influenza season. Clin Microbiol Infect. 2011 Dec 8; …
Importance of clinical and echocardiographic hemodynamic assessment in chronic pulmonary embolism.
Importance of clinical and echocardiographic hemodynamic assessment in chronic pulmonary embolism. J Cardiovasc Ultrasound. 2011 Dec;19(4):224-7 Authors:…
Continuous versus intermittent inhaled corticosteroid (budesonide) for mild persistent asthma in children--not too much, not too little
The clinical efficacy of inhaled corticosteroids (ICSs) in asthma has been demonstrated in long-term intervention studies,1 2 and ICSs are recommended first-line treatment of persistent asthma, even in children.3 The long-term benefits of early intervention with ICS have been well…
In search of the fibrotic epithelial cell: opportunities for a collaborative network
Idiopathic pulmonary fibrosis (IPF) is a chronic progressive disease of unknown aetiology. It has a very poor prognosis and no effective treatment. There are two major barriers to the development of novel treatments in IPF: an incomplete understanding of its…
Continuous versus intermittent inhaled corticosteroids for mild persistent asthma in children: not too much, not too little
The goal of asthma treatment is to prevent exacerbations, achieve daily asthma control and prevent adverse effects with a minimum of medication. In preschoolers, children and adolescents with mild persistent asthma, the most effective therapy remains daily use of low-dose…
Occupational exposure to organic dust increases lung cancer risk in the general population
Background Organic dust is a complex mixture of particulate matter from microbial, plant or animal origin. Occupations with exposure to animal products have been associated with an increased lung cancer risk, while exposure to microbial components (eg, endotoxin) has been associated…
Dyspnoea severity and pneumonia as predictors of in-hospital mortality and early readmission in acute exacerbations of COPD
Background Rates of mortality and readmission are high in patients hospitalised with acute exacerbations of chronic obstructive pulmonary disease (AECOPD). In this population, the prognostic value of the Medical Research Council Dyspnoea Scale (MRCD) is uncertain, and an extended MRCD (eMRCD)…
An Association Between Neutrophils and Immunoglobulin Free Light Chains in the Pathogenesis of COPD.
CONCLUSION: This study describes for the first time an association between neutrophils and IgLC in the pathophysiology of COPD, which could open new avenues to targeted treatment of this chronic disease. PMID: 22227380 [PubMed - as supplied…
Anaphylaxis as an adverse event following immunisation in the UK and Ireland.
Anaphylaxis is a rare adverse event following immunisation (AEFI) and unlikely to be detected in prelicensure vaccine trials. Previous retrospective studies have been hampered by the paucity of information available to passive reporting schemes. The aim of the present study was…
Inflammation and Coagulation in Urticaria and Angioedema.
Urticaria is a skin disease characterised by short-lived surface swellings of the dermis (wheals) frequently accompanied by itching. It is classified as acute or chronic depending on whether the wheal recurrence occurs for less or more than six weeks. Acute…
The Role of Natural Killer T Cells in the Pathogenesis of Acute Exacerbation of Human Asthma.
Natural killer T (NKT) cells have been reported to play a crucial role in the pathogenesis of asthma in a mouse model of acute asthma. The present study aimed to investigate the role of NKT cells in the immune pathogenesis…
Basophil Activation Test in Allergy: Time for an Update?
A wide range of reported evidence in the literature has shown that the quantification of basophil activation by flow cytometry (basophil activation test, BAT) has proven to be a useful tool for the assessment of immediate-type responses to allergens mediated…
Psychosocial stress and asthma morbidity.
Psychosocial stress and asthma morbidity. Curr Opin Allergy Clin Immunol. 2012 Jan 19; Authors: Yonas MA, Lange…
The regulation of fibrosis in airway remodeling in asthma.
The regulation of fibrosis in airway remodeling in asthma. Mol Cell Endocrinol. 2012 Jan 14; Authors: Royce…
Omalizumab beyond asthma.
Omalizumab beyond asthma. Allergol Immunopathol (Madr). 2012 Jan 18; Authors: Sanchez J, Ramirez R, Diez S, Sus…

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Treatment of COPD: the sooner the better?

Sep

2010

Treatment of COPD: the sooner the better?

Classical belief is that only smoking cessation, and not pharmacotherapy, beneficially affect disease progression in chronic obstructive pulmonary disease (COPD). In recent years, new data on pharmacotherapy of COPD became available that shed new light on this question. The present paper reviews these data critically in an attempt to put them in a proper perspective. The most impressive new data are subgroup analyses of two large-scale long-term trials. With these new data it is now clear that patients in GOLD (Global Initiative for Chronic Obstructive Pulmonary Disease) stage II benefit as much from pharmacotherapy as patients in the later stages of the disease. Effects on prebronchodilator and postbronchodilator forced expiratory volume in 1 s (FEV1), health-related quality of life, exac...

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Treatment of COPD: the sooner the better? Top