Lowdose Azithromycin Improves Phagocytosis Of Bacteria By Both Alveolar And Monocytederived Macrophagesin Copd Subjects

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Cognitive dysfunction in patients with chronic obstructive pulmonary disease – A systematic review

Publication year: 2012Source:Respiratory MedicineLone Schou, Birte Østergaard, Lars S. Rasmussen, Susan Rydahl-Hansen, Klaus Phanareth Background Substantial healthcare resources are spent on chronic obstructive pulmonary disease (COPD)....

Sam 19 05 2012 Bibliographie

Daily step counts in a US cohort with COPD

Publication year: 2012Source:Respiratory Medicine, Volume 106, Issue 7Marilyn L. Moy, Valery A. Danilack, Nicole A. Weston, Eric Garshick Background Baseline values for daily step counts in US...

Sam 19 05 2012 Bibliographie

Poor prediction of potentially drug-resistant pathogens using current criteria of health care-associated pneumonia

Publication year: 2012Source:Respiratory MedicineSeon Cheol Park, Young Ae Kang, Byung Hoon Park, Eun Young Kim, Moo Suk Park, Young Sam Kim, Se Kyu Kim,...

Sam 19 05 2012 Bibliographie

Arrhythmias as trigger for acute exacerbations of chronic obstructive pulmonary disease

Publication year: 2012Source:Respiratory MedicineSurya P. Bhatt, Sudip Nanda, John S. Kintzer Purpose Acute exacerbations of chronic obstructive pulmonary disease (COPD) sometimes appear to occur without a precipitating cause....

Sam 19 05 2012 Bibliographie

Patients’ experience of asthma control and clinical guidelines: Perspectives from a qualitative study

Clinical guidelines consider the concept of ‘asthma control’ as the primary goal of asthma treatment. This study aimed to explore patients’ views of concepts that are important for understanding and...

Ven 18 05 2012 Bibliographie

Association of adult-onset asthma with specific cardiovascular conditions

While asthma is known to be associated with cardiovascular disease (CVD), the relation to specific manifestations of CVD has not been previously described. Our objective was to explore the relation...

Ven 18 05 2012 Bibliographie

Cytokines in Induced Sputum: A Role for the Ratio of IL-6/IL-13 in the Differentiation of Asthma and Chronic Obstructive Pulmonary Disease

Source: Respiration

Ven 18 05 2012 Bibliographie

Mediastinal lymph node dissection in early-stage non-small cell lung cancer: totally thoracoscopic vs thoracotomy

OBJECTIVES Although major pulmonary resections for early-stage non-small cell lung cancer (NSCLC) are more and more frequently performed through thoracoscopy, the adequacy of lymphadenectomy achieved via this approach is still questioned....

Ven 18 05 2012 Bibliographie

Quality of life aids lung cancer prognosis

Self-reported quality of life at the time of lung cancer diagnosis has a significant impact on patients’ survival, show US study results.

Ven 18 05 2012 Bibliographie

Robotic lobectomy ‘accepted’ technique for NSCLC

Robotic-based video-assisted thoracic surgery lobectomy produces similar survival rates as conventional lobectomy when used in patients with non-small-cell lung cancer, report researchers.

Ven 18 05 2012 Bibliographie

Trials of bilevel positive airway pressure - spontaneous in patients with complex sleep apnoea.

Introduction: Patients with complex sleep apnoea (CompSAS) have obstructive sleep apnoea and experience persistent central apnoeas when exposed to positive airway pressure. Elevated loop gain is one...

Jeu 17 05 2012 Bibliographie

Factors influencing asthma course and the degree of control in the patients assessed with own questionnaire and Asthma Control Test (ACT).

Introduction: Asthma treatment requires control and monitoring. According to Global Initiative For Asthma (GINA) asthma severity is described by degree of control. The aim of the present...

Jeu 17 05 2012 Bibliographie

The influence of treatment with formoterol, formoterol with tiotropium, formoterol with inhaled glucocorticosteroid and tiotropium on lung functions, tolerance of exercise and simple, morning everyday activities in patients with COPD

Bronchodilators - long-acting b2-adrenergic agonists (formoterol and salmeterol) and a long-acting antimuscarinic drug (tiotropium), are the main drugs applied in symptomatic treatment of COPD. In patients with...

Jeu 17 05 2012 Bibliographie

Secondhand Smoke May Harm Heart Function

For nonsmokers, exposure to low levels of secondhand smoke for just 30 minutes can cause significant damage to the lining of their blood vessels, the results of a new study...

Jeu 17 05 2012 Bibliographie

'Self-Managing' COPD Might Pose Risks, Study Suggests

In a finding that seems counterintuitive, a new study revealed that people with chronic obstructive pulmonary disease (COPD) were more likely to die after receiving comprehensive education and self-management tools. "The...

Jeu 17 05 2012 Bibliographie

Recommendations and implementation of guidelines for community-acquired pneumonia: more problems than solutions

Pneumonia is the third leading cause of death worldwide and the leading cause of death in countries with low per capita income. It is responsible for a large number of...

Mer 16 05 2012 Bibliographie

Diurnal variations in the parameters of pulmonary function and respiratory muscle strength in patients with COPD

CONCLUSIONS: In this sample of COPD patients, there were diurnal variations in the parameters of pulmonary function and respiratory muscle strength. The values of FEV1, FVC, and MEP were significantly...

Mer 16 05 2012 Bibliographie

Adherence to guidelines and its impact on outcomes in patients hospitalized with community-acquired pneumonia at a university hospital

CONCLUSIONS: In the population studied, admission and treatment criteria that were in accordance with the guidelines were associated with favorable outcomes in hospitalized patients with CAP. Cerebrovascular disease, as a...

Mer 16 05 2012 Bibliographie

Lung ultrasound in critically ill patients: a new diagnostic tool

The objective of this review was to evaluate the clinical applications of lung ultrasound by searching the PubMed and the Brazilian Virtual Library of Health databases. We used the following...

Mer 16 05 2012 Bibliographie

Predicting Mortality among Older Adults Hospitalized For Community‐Acquired Pneumonia: An Enhanced Curb Score Compared With Pneumonia Severity Index

Conclusions: An enhanced CURB score predicted 30‐day mortality with at least the same accuracy as PSI class did among older adults hospitalized for CAP. External validation of this score in...

Mer 16 05 2012 Bibliographie

Food Allergies: The Implications for Correctional Facilities

The prevalence of food allergies in the inmate population is a relatively unknown and perhaps underreported health issue. An inmate with an undetected food allergy is at risk for anaphylaxis...

Mer 16 05 2012 Bibliographie

Dyspnea in patients with asthma, allergic rhinitis and mouth breathing

CONCLUSIONS: the major respiratory symptoms were found in physical activity associated with speech, followed by physical activity per se. Already in communicative activities, only activities that required more vocal intensity...

Mer 16 05 2012 Bibliographie

Antiproliferative action of metformin in human lung cancer cell lines.

The oral antidiabetic agent metformin has anticancer properties, probably via adenosine monophosphate-activated protein kinase activation. In the present study, growth inhibition was assessed by a clonogenic and by a cell survival...

Mar 15 05 2012 Bibliographie

Evaluation of the Use of a Rapid Diagnostic Consultation of Lung Cancer. Delay Time of Diagnosis and Therapy.

OBJECTIVE: To analyze the results obtained in a lung cancer screening program since its inception five years ago regarding correct referrals, diagnostic and therapeutic delay times and days of hospitalization....

Mar 15 05 2012 Bibliographie

Subsolid pulmonary nodules: imaging evaluation and strategic management.

Given the higher rate of malignancy of subsolid pulmonary nodules and the considerably lower growth rate of ground-glass nodules (GGNs), dedicated standardized guidelines for management of these nodules have been...

Mar 15 05 2012 Bibliographie

Use of lung cancer screening tests in the United States: results from the 2010 National Health Interview Survey.

Prior to evidence of efficacy, lung cancer screening was being ordered by many physicians. The National Lung Screening Trial (NLST), which demonstrated a 20 percent reduction in lung cancer mortality...

Mar 15 05 2012 Bibliographie

Matrix metalloprotease-1a promotes tumorigenesis and metastasis.

Matrix metalloprotease-1 (MMP1), a collagenase and activator of the G protein-coupled protease activated receptor-1 (PAR1), is an emerging new target implicated in oncogenesis and metastasis in diverse cancers. However, the...

Mar 15 05 2012 Bibliographie

Silicosis.

Silicosis is a fibrotic lung disease caused by inhalation of free crystalline silicon dioxide or silica. Occupational exposure to respirable crystalline silica dust particles occurs in many industries. Phagocytosis of...

Mar 15 05 2012 Bibliographie

T cell homing to epithelial barriers in allergic disease.

Allergic inflammation develops in tissues that have large epithelial surface areas that are exposed to the environment, such as the lung, skin and gut. In the steady state, antigen-experienced memory...

Lun 14 05 2012 Bibliographie

Smooth muscle in tissue remodeling and hyper-reactivity: Airways and arteries.

Smooth muscle comprises a key functional component of both the airways and their supporting vasculature. Dysfunction of smooth muscle contributes to and exacerbates a host of breathing-associated pathologies such as...

Lun 14 05 2012 Bibliographie

CT based computerized identification and analysis of human airways: A review.

As one of the most prevalent chronic disorders, airway disease is a major cause of morbidity and mortality worldwide. In order to understand its underlying mechanisms and to enable assessment...

Lun 14 05 2012 Bibliographie

Amnion epithelial cells as a candidate therapy for acute and chronic lung injury.

Acute and chronic lung injury represents a major and growing global burden of disease. For many of these lung diseases, the damage is irreparable, exhausting the host's ability to regenerate...

Lun 14 05 2012 Bibliographie

Relationship between lung function impairment and health-related quality of life in COPD and ILD.

Health-related quality of life (HRQL) measures have been correlated with lung function in patients with chronic obstructive pulmonary disease (COPD) and interstitial lung disease (ILD). However, different pathophysiologic mechanisms may...

Lun 14 05 2012 Bibliographie

Bronchoscopy for the diagnosis of pulmonary tuberculosis in patients with negative sputum smear microscopy results.

OBJECTIVE: To evaluate the diagnostic accuracy of bronchoscopy in patients with clinical or radiological suspicion of tuberculosis who were unable to produce sputum or with negative sputum smear microscopy results. METHODS:...

Lun 14 05 2012 Bibliographie

Usefulness of imprint and brushing cytology in diagnosis of lung diseases with flexible bronchoscopy.

Background : To increase the diagnostic yield in pulmonary diseases, histopathology, imprint cytology and brushing cytology are assessed in combination during flexible bronchoscopy. However, the individual diagnostic discrimination of the...

Lun 14 05 2012 Bibliographie

Clinical and cost effectiveness of mobile phone supported self monitoring of asthma: multicentre randomised controlled trial.

OBJECTIVE: To determine whether mobile phone based monitoring improves asthma control compared with standard paper based monitoring strategies. DESIGN: Multicentre randomised controlled trial with cost effectiveness analysis. SETTING: UK primary...

Sam 12 05 2012 Bibliographie

Recurrent Anaphylactic Reactions: An Uncommon Debut of Lymphocytic Hypophysitis.

We report on a 24-year-old male, with exercise-induced asthma and intermittent abdominal pain since puberty, who suffered from recurrent anaphylactic reactions. He also complained of occasional headaches. After extensive studies he...

Sam 12 05 2012 Bibliographie

Identification of budesonide metabolites in human urine after oral administration.

Budesonide (BUD) is a glucocorticoid widely used for the treatment of asthma, rhinitis, and inflammatory bowel disease. Its use in sport competitions is prohibited when administered by oral, intravenous, intramuscular,...

Sam 12 05 2012 Bibliographie

Omalizumab versus 'Usual Care': Results from a Naturalistic Longitudinal Study in Routine Care.

It is unclear how far the superior efficacy of omalizumab, established in randomized controlled clinical trials of patients with severe allergic asthma (SAA), translates into routine practice and when compared...

Sam 12 05 2012 Bibliographie

[Pharmacology of glucocorticoids].

Although Nobel Prize was attributed to three searchers more than 60 years ago for their discovery of corticosteroids, this therapeutic class remains one of the most prescribed nowadays. The mechanism of...

Sam 12 05 2012 Bibliographie

Inhaled and Systemic Corticosteroid Response in Severe Asthma Assessed by Alveolar Nitric Oxide: a randomised crossover pilot study of add-on therapy.
Alveolar nitric oxide (CA(NO) ) is a potential biomarker of small airway inflammation. We investigated effects on CA(NO) of the addition of coarse and fine particle inhaled corticosteroids to standard therapy in severe asthma. Methods: Severe asthmatics taking ≥1600µg/day budesonide or…
Mometasone/Formoterol Inhalation Aerosol: In Asthma Uncontrolled on Medium- or High-Dose Inhaled Corticosteroids.
The corticosteroid mometasone and the long-acting β(2)-selective adrenoreceptor agonist formoterol have been combined in a single pressurized metered-dose inhaler for use in patients aged ≥12 years with asthma. In a 26-week well designed trial in patients with persistent asthma uncontrolled on…
Treatment of Disorders Characterized by Reversible Airway Obstruction in Childhood: are Anti-cholinergic Agents the Answer?
Release of acetylcholine from parasympathetic nerves in the airways activates postjunctional muscarinic receptors present on smooth muscle, submucosal glands and blood vessels. This triggers bronchoconstriction, muscle hypertrophy, mucus secretion, and vasodilatation, respectively. The release of acetylcholine from parasympathetic nerves in…
Macrolides for macrophages in COPD.
Chronic obstructive pulmonary disease (COPD) represents one of the major causes of mortality and morbidity worldwide. The pathogenesis of COPD is complex and multi-factorial, and is mediated by both pulmonary and systemic factors. Patients with COPD suffer frequent exacerbations that require…
The Relationship between Telomere Length and Mortality in Chronic Obstructive Pulmonary Disease (COPD).
Some have suggested that chronic obstructive pulmonary disease (COPD) is a disease of accelerated aging. Aging is characterized by shortening of telomeres. The relationship of telomere length to important clinical outcomes such as mortality, disease progression and cancer in COPD…
Vitamin D and skeletal muscle strength and endurance in chronic obstructive pulmonary disease.
It is not known whether vitamin D levels make a significant contribution to muscle dysfunction in COPD. In 104 COPD patients (mean(SD) FEV1 44(22)%predicted) and 100 age and sex-matched controls serum 25(OH)D, 1,25(OH)2D and parathyroid hormone levels were measured and related…
Cerebral cortex oxygen delivery and exercise limitation in patients with COPD.
In healthy humans, cerebral oxygen desaturation during exercise affects motor unit recruitment, whilst oxygen supplementation enhances cerebral oxygenation and work capacity. It remains unknown whether in patients with COPD the well documented improvement in exercise tolerance with oxygen supplementation may…
Mesenchymal stem cells.
Mesenchymal Stem cells (MSCs) are stromal cells that can be readily harvested from adult bone marrow and adipose tissue, but also umbilical cords. With respect to respiratory disease, the therapeutic potential of these cells lies in their paracrine effects which…
Bronchodilators in Heart Failure Patients With COPD: Is It Time for a Clinical Trial?
Chronic heart failure (HF) and chronic obstructive pulmonary disease (COPD) commonly coexist, and patients with both diseases fare worse than those with either disease alone. Several factors may contribute to worse outcomes, including an increased burden of care related to…
Heart disease risk can indicate long-term COPD fate
Knowledge of cardiovascular disease risk significantly improves prognostication among patients with chronic obstructive pulmonary disease, study findings indicate. (Source: MedWire News - Respiratory)
Zinc 'can cut length of common cold'
Conclusion For many years, it has been suggested that zinc supplements could relieve the symptoms of the common cold, but there was little clarity until a 2011 evidence review. This recent review suggested a modest reduction in the length of symptoms,…
Asthma an Often Unrecognized Risk for Older People
Title: Asthma an Often Unrecognized Risk for Older PeopleCategory: Health NewsCreated: 5/5/2012 11:01:00 AMLast Editorial Review: 5/7/2012 12:00:00 AM (Source: MedicineNet Asthma General)
Determination of Tobacco Smoke Exposure by Plasma Cotinine Levels in Infants and Children Attending Urban Public Hospital Clinics [Article]
Conclusion In a city with a low smoking rate (12%) and public smoking bans, we documented 55% exposure among infants and young children, using a plasma biomarker, compared with 13% exposure reported by parents. Because SHS is associated with significant…
Influence of age on the clinical differentiation of atypical pneumonia in adults
Conclusions: These results indicate that it is difficult to distinguish between atypical pneumonia and bacterial pneumonia in the elderly, using the JRS scoring system. When treating patients aged ≥60 years, physicians should use fluoroquinolones or β‐lactam antibiotics + macrolides as…
Depression but not sleep disorder is an independent factor affecting exacerbations and hospitalization in patients with chronic obstructive pulmonary disease
Conclusions: Depression and sleep disorders are very common comorbidities among COPD patients, and significantly reduce activities and HRQOL among these patients. Depression, but not sleep disorder, is an independent risk factor for exacerbations and hospitalization among COPD patients.© 2012 The…
Updates in oral appliance therapy for snoring and obstructive sleep apnea
Conclusion Consistent follow-up and management are needed to increase clinical success rates in OA therapy for OSA. Further educational preparation and support is required for dental and medical professionals to recognize OSA and ensure the best possible patient care. …
Ventilatory and cardiocirculatory exercise profiles in COPD: the role of pulmonary hypertension.
CONCLUSION:Patients with severe PH showed an exhausted circulatory reserve at the end of exercise. A profile of circulatory reserve in combination with ventilatory impairments was found in COPD-patients with moderate PH or no PH. The results suggest that pulmonary vasodilation…

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Low‐dose Azithromycin improves phagocytosis of bacteria by both alveolar and monocyte‐derived macrophagesin COPD subjects

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Low‐dose Azithromycin improves phagocytosis of bacteria by both alveolar and monocyte‐derived macrophagesin COPD subjects

Conclusions : The data provide further support for the long term use of low dose azithromycin as an attractive adjunct treatment option for COPD. Improved clearance of both apoptotic cells and bacteria in the airway may have a dual effect; reducing the risk of secondary necrosis and release of toxic cell contents that perpetuate inflammation as well as contributing to a reduction in the rate of exacerbations in COPD.© 2012

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Low‐dose Azithromycin improves phagocytosis of bacteria by both alveolar and monocyte‐derived macrophagesin COPD subjects Top